The development of drugs with poorly soluble to insoluble active ingredients is a big challenge for the pharmaceutical industry. The bioavailability of orally taken active ingredients, which means to what extent and in which period of time the substance is ingested by the body and is available at the place of action, strongly depends on the percentage dissolved in the gastrointestinal tract. One way to improve the solubility and thus the bioavailability of active ingredients is the pulverization of these substances. By minimizing the particle size to the micron and submicron range the surface-volume-ratio is increased and the solubility of the particles is improved. The pulverized particles are suitable for use in a variety of dosage forms, for example classic tablets or capsules.