Joint replacements, especially of hip and knee joints, rank among the most frequent surgical interventions in industrialized countries. One of the major risks of a joint replacement is prosthetic joint infection (PIJ), a bacterial infection at the interface of implant, tissue, and bone. In 2010, A.-L. Roux et al. published an article titled „Diagnosis of prosthetic joint infection by beadmill processing of a periprosthetic specimen.“ It describes a new diagnosis method of involved microbes, with an impressive documentation rate of more than 83% and, at the same time, a very low contamination rate of 8.7%. The method involves washing the microbes off the tissue samples with 20 ml sterile water and 5 ml glass beads of 1 mm diameter at 30 Hz in a RETSCH Mixer Mill within 210 seconds.